Thymus Cancer Market Lucrative Opportunities across Globe

​Thymus is an irregular shape gland which is located under the breastbone (sternum) in upper chest. The organ is divided into two halves known as lobes and is made up of many small bumps called as lobules. Thymus plays an important role in maintaining the body’s immune system. During fetal development and childhood thymus gland is involved in the production and maturation of T lymphocytes (T cells). T cells are developed in the thymus and travel to lymph nodes throughout the body. These T cells are responsible for fighting against viruses, bacteria, fungi and various other infection causing agent. Thymus gland is fully developed at the age of puberty but gradually the gland shrinks and becomes inactive. However, the gland continues to produce T cells until old age.

Thymus cancers (Thymomas and thymic cancers) are rare tumors and originate from thymic epithelial cells. It is estimated, in the U.S that approximately 400 cases per year are diagnosed for thymus cancers. People suffering from thymomas show symptoms of shortness of breath, cough, chest pain, weight loss and others. The cancer is benign and people aged between 40 years and 60 years are usually diagnosed with thymomas. As thymus gland is involved in production of T cells, people suffering from thymus cancers tend to show immune system related illness. For, instance 30% to 50% of people suffering from thymomas show myasthenia gravis (MG), disease condition in which immune system forms antibodies for blocking chemical signals required for muscle movement.

Currently, thymus cancers are diagnosed with the help of various tests including chest X-ray, CT scan, PET scan, Needle biopsy, MRI scan, thoracoscopy and mediastinoscopy. Additionally, surgery and chemotherapy are the main treatment options available for the removal of thymus cancers. Further, clinical trials are being conducted for the treatment of thymus cancer. Some of major players involved in conducting clinical trial therapeutics are Novartis AG, Enzon Pharmaceuticals, Inc. and Nerviano Medical Sciences S.r.l.

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The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.

The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industry’s value chain.

A separate analysis of prevailing trends in the parent market, macro- and micro-economic indicators, and regulations and mandates is included under the purview of the study. By doing so, the report projects the attractiveness of each major segment over the forecast period.

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Angioimmunoblastic T Cell Lymphoma Immunoblastic Lymphadenopathy Market Competitive Dynamics & Global Outlook 2024

​Angioimmunoblastic T Cell Lymphoma Immunoblastic Lymphadenopathy Market also known as Immunoblastic Lymphadenopathy is a grown T-cell lymphoma of blood distinguished by a polymorphous lymph node penetrate resulting significant increase in follicular dendritic cells (FDCs) and high endothelial venules (HEVs) with systemic involvement. Clinically this disorder is characterized by generalized lymphadenopathy and high fever. This disorder progresses in series of diseases such as cutaneous involvement, hepatosplenomegaly, hemolytic anemia and polyclonal hypergammaglobulinemia. The symptoms observed in a patient suffering from angioimmunoblastic T-cell lymphoma are weight loss, polyclonal hyperglobulinemia, hepatomegaly and generalized adenopathy. The other problems accompanying angioimmunoblastic T-cell lymphoma (AILT)/ immunoblastic lymphadenopathy are multicentric giant lymph node hyperplasia, acute viral lymphadenitis, hypersensitivity syndrome, lymphoma, leukemia, Crohn’s disease and a typical linear immunoglobulin A dermatosis. The standard staging of angioimmunoblastic T-cell lymphoma (AILT) is explained with Ann Arbor system that was developed for Hodgkin disease. The stages involved in angioimmunoblastic T-cell lymphoma (AILT) are as follows:

Stage I – Involvement of a single lymph node region

Stage II – Involvement of two or more lymph node regions on the same side of the diaphragm

Stage III – Involvement of lymph node regions on both sides of the diaphragm and localized involvement of an extralymphatic site

Stage IV – Diffuse involvement of one or more extralymphatic organs with or without associated lymph node involvement

The diagnosis of angioimmunoblastic T-cell lymphoma (AILT)/ immunoblastic lymphadenopathy is done initially with physical symptoms detection such as night sweats, fever, swollen lymph nodes, chills, skin rash and weight loss. The diagnosis helps to understand the staging of angioimmunoblastic T-cell lymphoma (AILT) and is carried out with follow-up tests such as CT scans, X-rays, PET scans and bone marrow biopsies. The therapeutic treatment of angioimmunoblastic T-cell lymphoma (AILT) consists of initial doses of steroids to reduce inflammation pain and skin irritation. Post steroid therapy CHOP chemotherapy treatment a cycle of 4 weeks is applied to treat cancer. The CHOP chemotherapy consists of drugs such as cyclophosphamide, doxorubicin, vincristine, and prednisone along with radiation therapy. The treatments that are under pipeline include the drugs such as Alemtuzumab, Bevacizumab, Cyclosporine, Lenalidomide, Romidepsin and Pralatrexate. According to Centers for Disease Control and Prevention (CDC), in 2012 it was found that approximately 1% – 2% of non-Hodgkin lymphomas are associated with angioimmunoblastic T-cell lymphoma (AILT). Although, angioimmunoblastic T-cell lymphoma (AILT) has been reported in children, most patients are middle aged or elderly of the age group above 60 years.

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North America was observed to be the largest market for angioimmunoblastic T-cell lymphoma (AILT)/ immunoblastic lymphadenopathy diagnosis and treatment. Advanced technologies and high awareness are the major driving factors of this market. Europe was observed to be the second largest market and one of the leading research destinations for neurological and carcinogenic diseases diagnosis and treatment. Asia-Pacific and Rest of the World were observed to be the most potential markets for angioimmunoblastic T-cell lymphoma (AILT)/ immunoblastic lymphadenopathy diagnosis and treatment market. These regions lack in advanced infrastructure and disease awareness. The future growth in these geographical regions is expected due to the presence of emerging economies such as China, India, Brazil and other countries that primarily prefer healthcare sector for developmental investment.

Some of the key players involved in the global clinical trials of angioimmunoblastic T-cell lymphoma (AILT)/ immunoblastic lymphadenopathy are Takeda Pharmaceutical Company Limited, Newport Pharmaceuticals Limited, Eisai Inc., Cellerant Therapeutics, Inc., National Cancer Institute, Fred Hutchinson Cancer Research Center, Ohio State University Comprehensive Cancer Center are among others.

Allergen Extracts Market Competitive Dynamics & Global Outlook 2024

​Allergen extract is a mixture of various naturally occurring compounds such as allergens, proteins and other enzymes that are obtained from allergic sources including pollen, animal hair, molds, and insects. Naturally occurring compounds are used to test antibody response when exposed to various allergens and other immunotherapeutic tests. Allergens are used in diagnosis and treatment of allergic rhinitis (hay fever), conjunctivitis, sinusitis and allergies caused by food and animal venoms. Based on the route of administration, allergen extracts are categorized as follows:

Injectable allergen extracts

Oral allergen extracts

Injectable allergen extracts are sterile liquids mixed with allergen compounds manufactured from different natural allergen sources. Injectable allergen extracts are used mainly for diagnosis and treatment of food allergies and dermatitis caused by allergic substances. Allergen extracts are used for diagnostic purpose in food allergies. Injectable allergen extracts are administered through subcutaneous layer since it may cause heightened allergic reactions when given intravenously. Injectable allergen extracts are further categorized into two types namely standardized and non-standardized. Standardized allergen extracts have known potency while non-standardized extracts has no known measure of potency. Oral allergen extracts are available in tablet form intended for oral administration to test allergic reactions. Oral allergen extracts are used in the treatment of hay fever, and allergic conjunctivitis. Some of the commercially available oral administration allergen extracts include sublingual tablets namely, Grastek, Oralair and Ragwitek.

Furthermore, less popular diagnostic tests available in the market include allergen patch tests and allergen skin tests. Allergen patch tests are also referred as Thin Layer Rapid Use Epicutaneous Patch tests (T.R.U.E test). T.R.U.E patch test is used to diagnose different forms of contact dermatitis and is manufactured from various natural allergic substances or chemicals such as nickel, rubber and other elicit substances (fragrant mixes). T.R.U.E. patch test is commonly used in adults having allergic history from one of the 35 different allergens stated under T.R.U.E test standards. Antigen skin tests are used to diagnose allergies caused by different pathogens such as Candida albicans and Mycobacterium tuberculosis.

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The market for allergen extracts is anticipated to grow owing to perpetually rising demand for immunotherapeutic diagnosis and treatment of different diseases caused by allergens. The U.S. is the largest market for allergen extracts and is expected to show positive growth during the forecast period from 2014 to 2020. Factors such as high demand of oral administration allergen extracts over subcutaneous administration allergen extracts are driving the growth of allergen extracts market in the U.S. Merck & Co., Inc. and Greer are expected to lead the allergen extract market in the U.S. Europe has large potential for growth of the allergen extracts market especially for the subcutaneously administered allergy extracts. However economic slowdown of healthcare expenditure in Europe is restraining the growth of allergen extracts market. Asia Pacific market is anticipated to expand during the forecast period from 2014 to 2020 owing to launch of new sublingual allergy extract therapies in the Japanese market by local manufacturers. Rest of the world (RoW) countries mainly Latin American countries are expected to increase the potential of global allergen extract market in near future. Some of the major players in the allergen extract market are Greer, ALK-Abello, Allergopharma (Merck), Genentech, Roche, Shionogi & Co., Novartis, HollisterStier Allergy, MSD (Merck & Co.) and others.

The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.

Airway Stenting Market Competitive Dynamics & Global Outlook 2024

​Airway stents or tracheobronchial prostheses refer to the tube shaped devices inserted into an airway and this process is referred to as interventional pulmonary or airway stenting. Airway stenting relieves airway obstruction due to the structures that are not suitable for reconstruction and resection. Tracheobronchial disorders are majorly caused due to the presence of benign or malignant tumors, post intubation tracheal injuries, extrinsic compression and tracheobronchomalacia post tracheostomy. Currently, there are two major types of airway stents available namely expandable metallic stents and silicon tube stents. Metallic stents are further classified as uncovered and fully covered forms. Metal stents can be inserted with the help of a flexible bronchoscope while silicon stents are placed with the help of a rigid bronchoscope when the patient in under general anesthesia. Primarily, removable stents are preferred in case of the treatment for benign disorders.

The treatment of primary and metastatic lung cancer is the most common condition treated with the help of airway stents rendering an unobstructed airway. Other indications include primary airway tumors, thyroid cancer, inflammatory lesions, vascular compression, head and neck tumors, oesophageal cancer, idiopathic benign tracheal stenonsis and others. This process ensures durable palliation in unresectable patients with central airway obstruction and there is a need for frequent multiple procedures and stents to maintain unobstructed airway.

The choice of stent depends on the type of lesion to be treated, resource availability and in the presence of a dedicated operator. Proper stent sizing can be achieved by reviewing the computed tomography images and other methods. The length is a stent to be used is a very critical parameter to be considered in order to ensure proper functioning of these stents. For instance, if the diameter if these stents is too small than the size if the lesion, then they might migrate from its original position and of the length of the stent is too large, it might cause stress on the airway wall, hence, the length of the stent should exceed the length of the lesion to some degree. Migration of the stent results in several side effects such as breakage of metal fibers, granuloma formation, hemoptysis and pain.

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The placement of the stent should be avoided in case of a non-viable lung. Placement of the stent should be performed by highly trained pulmonologists. It is mandate for the trainees to perform atleast 20 supervised procedures in order to establish a basic competency and to maintain the competency these operators should perform more than 10 procedures per year and furthermore these operators should be proficient in placement of both silicone and flexible stents.

The market for airway stents can be segmented by type and applications. Metallic and silicone stents are the two major types of airway stents available commercially. Factors such as patient safety, proficiency in stent placement and other regulatory policies govern the market growth. Geographically, North America and Europe regions are the major revenue contributors to this market majorly due to increasing incidence of lung cancers and high disposable incomes. Asia Pacific and Rest of the World provide lucrative business opportunities in this area owing to the large patient population and improved healthcare facilities.

The major factors favoring the airway stent market are consistent increase in lung cancer incidence worldwide and development of novel and efficient stents to treat airway disorders. On the other hand factors such as lack of trained operators and side effects caused due to migration of the stents might hamper the acceptance thereby affecting the market growth. Novatech SA, Boston Medical Products, Inc., Boston Scientific Corporation, TAEWOONG Medical Co., Ltd. constitute some of the companies operating in this market.

The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.

Clinical Laboratory Services Market Companies Focus on Technological Advancements to Surge Ahead

​The global clinical laboratory services market demonstrates a largely fragmented business landscape due to the presence of a large pool of international and regional players, states a recent market intelligence report by Transparency Market Research (TMR). Keen players in the market are pouring money for facility automation and for the inclusion of technologically advanced tests as well as to expand their existing capacities that will help them serve a large customer base. They are also seen to expand their geographical outreach with mergers and acquisitions and strategic alliances, which is making the market somewhat consolidated.

Key companies operating in the global clinical laboratory services market include Charles River Laboratories International Inc., SYNLAB International GmbH, Sonic Healthcare, NeoGenomics Laboratories Inc., Genomic Health Inc., Fresenius Medical Care, Laboratory Corporation of America Holdings, UNILABS, Quest Diagnostics Incorporated, and Eurofins Scientific among others.

According to TMR’s estimations, the worldwide market for clinical laboratory services will serve a demand to attract a revenue of US$361.3 bn by the end of 2025 from US$208.0 bn in 2016 at a CAGR of more than 6% from 2016 to 2025.

Based on test type, clinical chemistry test segment is likely to lead the global market through 2025. The segment of standalone laboratories among the various service provider segments holds dominance in this market. However, hospital based laboratories segment is expected to display the leading growth rate among all service provider segments over the forecast period. Geography-wise, North America is anticipated to continue to dominate in the global clinical laboratory services market over the forecast period.

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Rising Awareness about Importance of Early Disease Diagnosis Boosts Market’s Growth

High prevalence of infectious diseases is one of the key factors driving the growth of global clinical laboratory services market. This, along with the rising awareness about the importance of disease diagnosis, incidence of seasonal diseases, and prevalence of lifestyle related diseases are attributed to drive the growth of clinical laboratory services market during the forecast period.

In the present scenario, advanced technologies, demand for quick results, and revolution in testing methodologies are some of the key factors that are likely to propel the market’s growth over the forecast period. Consumers are aware of the availability of tests that help diagnose the condition at an early stage and administer the course of treatment. Furthermore, rise in per capita healthcare expenditure by consumers, government funding for modernization of laboratory services in emerging economies, and increasing global population are expected to stoke growth of the clinical laboratory services market in the upcoming years.

Clinical laboratory refers to a facility where tests are performed on the clinical specimen to obtain information about the medical condition of patients so as to diagnose and deliver the line of treatment in a timely manner. The tests help physicians to understand the root cause of the disease and subsequently administer appropriate treatment.

Lack of Technical Expertise in Developing Nations Hinders Growth

On the downside, factors such as lack of awareness in developing countries about the importance of diagnosis and prevention of diseases, lack of infrastructure and dearth of expert technicians in developing nations, and stringent regulatory scenarios in many countries are restricting the growth of clinical laboratory services market.

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Nurse Call Systems Market Lucrative in Various Regions

​A recent market intelligence report by Transparency Market Research (TMR) has detected that the global nurse call systems market is constantly evolving with the advent of new equipment and features, and although there is plenty of scope for new entrants who frequently make a foray, a limited number of key players do hold a significant position. Some of the major players identified by the TMR report in the global nurse call systems market are: Cornell Communications, Azure Healthcare Limited, TekTone Sound & Signal Mfg., Inc., Ascom Holding AG, Jeron Electronic Systems, Inc., Hill-Rom Holdings, Inc., STANLEY Healthcare, Vigil Health Solutions, Inc., Tyco SimplexGrinnell, and Rauland-Borg Corporation, which has been acquired by Ametek, Inc.

The TMR report projects the demand in the global nurse call systems market to expand at an impressive CAGR of 10.9% during the forecast period of 2017 to 2025, estimating it to reach a valuation of US$2,665.98 mn by 2025. Most of the key vendors are resorting to latest technologies in order to differentiate themselves from the competition and gain market share. The report also expects offering of customized services according to the requirements of individual hospital, acquisitions of promising entrants, significant contract wins, and new product launches as some of the other strategies of the key players to expand their revenue horizon.

Based on equipment-type, IP-based nurse call systems generated maximum revenue in 2016, whereas wired communication contributed maximum demand in terms of communication technology. End-users of the global nurse call systems market has been bifurcated into hospitals, assisted living centers, nursing homes, and clinics, with hospitals offering most of the demand, owing to growing adoption of nurse call systems at all-in-one healthcare facilities. Geographically, North America is the most profitable region, with robust medical infrastructure, although Asia Pacific is projected for the best growth rate.

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Increased Healthcare Budget and Government Support Driving Demand

Increase in healthcare expenditure, especially in the developed countries, growing adoptability of medical insurance in various emerging economies, aging population across the world, prevalence of chronic diseases, increased investment in healthcare, government support from innovative technology that come to consumer’s aid in real-time, technological advancements and product development, and easy data availability for important healthcare departments are some of the primary factors driving the global nurse call systems market.

As per the estimations of the World Health Organization, world’s population with people over 60 years of age will almost double from 12% to 22% during the period of 2015 to 2050. As geriatrics commonly suffer from various chronic diseases and are frequently unable to help themselves, this significant chunk of population will continue to pose strong demand in the global nurse call systems market. On the other hand, factors such as high implementation costs, challenges pertaining to integration and interoperability, stringent regulatory environment, and the lack of trained professionals who can function efficiently with healthcare as well as IT are hindering the market for nurse call systems from attaining its true potential.

Increasing Nurse Involvement in Healthcare Opening New Opportunities

Upcoming technologies such as centralized nurse call system, integration of nurse call systems with smartphones and in-hospital wireless phones, interoperable designs, and increasing nurse involvement in healthcare are some of the trends that are expected to reflect positively on the global nurse call systems market. The author of the report suggests the vendors of this market to pay deserving focus to the Asian countries wherein medical tourisms sector is prospering.

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Digital Health Market for Government Policies Creates Better Opportunities

​The global digital health market has been prognosticated to testify the existence of leading companies that showcase a grander regional outreach on account of their involvement in a range of digital health product categories. According to a report by Transparency Market Research (TMR), some of the dominant players operating in the market could be Philips Healthcare, McKesson Corporation, Allscripts Healthcare Solutions, Inc., Cerner Corporation, and Agfa-Gevaert N.V. The players have been circumstantially profiled in the report on the basis of various aspects such as recent developments, product portfolio, and key business strategies.

As per the statistics of TMR, the global digital health market has been envisaged to rake in a revenue of US$536.6 bn by the end of 2025 from US$196.3 bn in 2017 at a 13.4% CAGR. With regard to revenue, healthcare information systems had accounted for a king’s share in 2016. On the basis of regional distribution, North America had taken the lead in the market in the same year.

Developing IT Infrastructure and Advantageous Government Support Raise Expectations

The world digital health market has been prophesied to gain a strong impetus due to the surging adoption of IT in the healthcare industry and growing count of government initiatives in favor of healthcare providers and also patients. The rapid improvement of healthcare IT infrastructure and rising usage of mobile platforms such as tablets and smartphones could bode well for the market. Healthcare providers have been anticipated to up the adoption of mHealth technologies for monitoring the health of patients in view of the elevating pressure for cost reduction.

The practice of digital health in the U.S. has been receiving a telling boost owing to the striking increase in the usage of smartphones by physicians. The world digital health market has been predicted to ride its growth on the back of the advent of technologically sophisticated healthcare IT facilities backed by promising government support. The market could boast of a robust growth platform considering the fruitful integration of healthcare systems with enhanced government support.

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Inadequate Infrastructure and Expensive Maintenance Depress Demand

The other side of the coin could reveal a slack in growth for the international digital health market. This has been envisioned to be because of certain factors such as the poor size of healthcare infrastructure in emerging countries, high maintenance bills, security and privacy issues, and extortionate capital outlay.

However, the international digital health market has been foreseen to offer a wealth of auspicious business prospects in respect of the emergence of remote patient monitoring services that allow to examine health problems from remote locations. The adoption of these services has been expected to propel due to the burgeoning prevalence of diabetes, cancer, cardiovascular, and other diseases. The market could also expect opportunities birthing from the rise of geriatric population living independently and profiting from remote patient monitoring services.

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